Parkinson's Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Parkinson's Disease, including details on symptoms, treatment, genetics, medication.

Nurr1 mutational screen in Parkinson's disease.

Tan EK, Chung H, Chandran VR, Tan C, Shen H, Yew K, Pavanni R, Puvan KA, Wong MC, Teoh ML, Yih Y, Zhao Y

Division of Research, SingHealth, Singapore. gnrtek@sgh.com.sg

We performed sequence analysis of all the exons and exon-intron boundaries in familial and young-onset Parkinson's disease (PD) in an Asian cohort. None of the patients carried any pathogenic mutations in the Nurr1 gene. We demonstrated a 5 to 10% prevalence of the intron 7 +33 C-->T variant among Malay and Indian PD and healthy controls, suggesting that this variant, which was previously described only in 1 Chinese patient, was not a silent mutation but a common polymorphic variant in some ethnic races.

Published 3 November 2004 in Mov Disord, 19(12): 1503-5.
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