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Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease.

Martinez M, Brice A, Vaughan JR, Zimprich A, Breteler MM, Meco G, Filla A, Farrer MJ, Bétard C, Singleton A, Hardy J, De Michele G, Bonifati V, Oostra BA, Gasser T, Wood NW, Dürr A

INSERM EMI00-06, Evry, France.

Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease.

Published 5 July 2005 in Am J Med Genet B Neuropsychiatr Genet, 136(1): 72-4.
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