Parkinson's Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Parkinson's Disease, including details on symptoms, treatment, genetics, medication.

Comprehensive association analysis of the NOS2A gene with Parkinson disease.

Schulte C, Sharma M, Mueller JC, Lichtner P, Prestel J, Berg D, Gasser T

Hertie-Institute for Clinical Brain Research, Section for Neurodegenerative Diseases, University of Tübingen, Hoppe-Seyler Str. 3, 72076 Tübingen, Germany.

Inducible nitric oxide synthase (NOS2A) may be involved in the oxidative stress pathology of Parkinson disease (PD). Two previous studies reported an association of a single nucleotide polymorphism (rs1060826) with PD. A replication study of 340 German patients and 680 controls showed no significant association between 12 genotyped polymorphisms and PD. NOS2A is therefore not a major susceptibility locus in our relatively young sample population.

Published 12 December 2006 in Neurology, 67(11): 2080-2.
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