Parkinson's Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Parkinson's Disease, including details on symptoms, treatment, genetics, medication.

Nuclear localization of the 20S proteasome subunit in Parkinson's disease.

Nakamura A, Kitami T, Mori H, Mizuno Y, Hattori N

Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.

Considering the involvement of ubiquitin-proteasome system (UPS) in Parkinson's disease (PD), the aim of the present study was to determine the distribution of proteasomes in PD brains. Immunohistochemical studies showed localization of 20S proteasome in the nuclei of neurons of the putamen and substantia nigra of PD. In contrast, no nuclear staining was observed in the same areas of brains of controls. Our results suggest that nuclear localization of 20S proteasome seems to be associated with the pathogenesis of PD.

Published 28 August 2006 in Neurosci Lett, 406(1): 43-8.
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