Parkinson's Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Parkinson's Disease, including details on symptoms, treatment, genetics, medication.

Movement-related cortical activation in familial Parkinson disease.

Delval A, Defebvre L, Labyt E, Douay X, Bourriez JL, Waucquiez N, Derambure P, Destée A

Department of Clinical Neurophysiology, Hospital R. Salengro, Regional University Hospital, Lille, France.

We sought to determine whether or not first-degree relatives of patients with familial Parkinson disease (FDRs) present impaired movement-related cortical activity. We studied 10 familial Parkinson disease subjects, 10 FDRs, and 10 controls and analyzed event-related mu desynchronization (ERD) and beta synchronization. Forty percent FDRs presented reduced premovement mu ERD latency, suggesting that premovement cortical activation is impaired in FDRs.

Published 26 September 2006 in Neurology, 67(6): 1086-7.
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