Parkinson's Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Parkinson's Disease, including details on symptoms, treatment, genetics, medication.

Evaluation of LRRK2 G2019S penetrance: relevance for genetic counseling in Parkinson disease.

Goldwurm S, Zini M, Mariani L, Tesei S, Miceli R, Sironi F, Clementi M, Bonifati V, Pezzoli G

Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy. goldwurm@parkinson.it

We report the results of a family-based study of LRRK2 G2019S penetrance in Parkinson disease. We studied 19 families identified through the analysis of unrelated consecutive patients. The cumulative incidence of the disease was 15% at 60 years, 21% at 70 years, and 32% at 80 years. This study provides accurate estimates of G2019S penetrance by minimizing the selection bias.

Published 3 April 2007 in Neurology, 68(14): 1141-3.
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