Parkinson's Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Parkinson's Disease, including details on symptoms, treatment, genetics, medication.

The G2019S LRRK2 mutation is uncommon amongst Greek patients with sporadic Parkinson's disease.

Kalinderi K, Fidani L, Bostantjopoulou S, Katsarou Z, Kotsis A

Department of General Biology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting approximately 2% of the population >60 years of age. Although, the etiology of PD is still unknown, the genetic background of the disease has been documented. Recently, a mutation in the LRRK2 gene, G2019S, was associated with 3-41% and 1-2% of familial and sporadic PD, respectively suggesting a pivotal role of LRRK2 in PD. In this report, we examine the association of the G2019S mutation with sporadic late-onset PD, in an independent cohort of Greek patients and controls.

Published 20 September 2007 in Eur J Neurol, 14(10): 1088-90.
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