Parkinson's Disease Research Today is a free monthly online journal that collates and summarizes the latest research about Parkinson's Disease, including details on symptoms, treatment, genetics, medication.

Inflammation-related genes and the risk of Parkinson's disease: a multilocus approach.

Infante J, García-Gorostiaga I, Sánchez-Juan P, Sánchez-Quintana C, Gurpegui JL, Rodríguez-Rodríguez E, Mateo I, Berciano J, Combarros O

Service of Neurology and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, University Hospital Marqués de Valdecilla (University of Cantabria), Santander, Spain. jinfante@humv.es

For the first time, the multilocus approach by the set-association method has been applied for the analysis of a cluster of five genes [tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), IL-8, IL-1alpha and IL-10] involved in the brain neuroinflammatory pathway in Parkinson's disease (PD), in a well-defined group of 197 PD patients and 173 control subjects from Spain. Set-association analysis did not reveal an independent or an interactive effect of these inflammatory genes on the PD risk.

Published 20 March 2008 in Eur J Neurol, 15(4): 431-3.
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